Selected article for: "adverse effect and potential adverse effect"
Author: Bein, Thomas; Grasso, Salvatore; Moerer, Onnen; Quintel, Michael; Guerin, Claude; Deja, Maria; Brondani, Anita; Mehta, Sangeeta
Title: The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia
  • Document date: 2016_4_4
    • ID: krpg9u1u_23
    Snippet: The open lung approach may dramatically improve oxygenation, while minimizing VALI. The potential for alveolar recruitment in the individual patient is unfortunately extremely variable and difficult to estimate a priori [42] . As a general rule, patients with early, diffuse ARDS are good recruiters, whereas patients with late ARDS (>1 week) or focal ARDS are not [35, 43] . In poor recruiters, the open lung approach may induce alveolar hyperinflat.....
    Document: The open lung approach may dramatically improve oxygenation, while minimizing VALI. The potential for alveolar recruitment in the individual patient is unfortunately extremely variable and difficult to estimate a priori [42] . As a general rule, patients with early, diffuse ARDS are good recruiters, whereas patients with late ARDS (>1 week) or focal ARDS are not [35, 43] . In poor recruiters, the open lung approach may induce alveolar hyperinflation and hence VALI [31] . The stress index (identification of injurious mechanical ventilation from the shape of the pressure-volume curve) could be a valuable tool to monitor open lung approach-induced hyperinflation [11] . Another potential adverse effect of the open lung approach is the hemodynamic impairment due to reduced preload or increased right ventricular afterload [44] .

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