Author: Hong, Kyung-Wook; Choi, Su-Mi; Lee, Dong-Gun; Cho, Sung-Yeon; Lee, Hyo-Jin; Choi, Jae-Ki; Kim, Si-Hyun; Park, Sun Hee; Choi, Jung-Hyun; Yoo, Jin-Hong; Lee, Jong-Wook
Title: Lower Respiratory Tract Diseases Caused by Common Respiratory Viruses among Stem Cell Transplantation Recipients: A Single Center Experience in Korea Document date: 2017_3_1
ID: k8mn9xkj_21
Snippet: CRV infection may contribute to sustained inflammation or activation of an inflammatory process that leads to irreversible airway damage, and can cause late airflow obstruction in SCT recipients. 31 Furthermore, CRV infections frequently coexist with bacterial or fungal pathogens, contributing to the development of pneumonia. It may be the result of epithelial damage, impaired ciliary function, an altered immune response, or upregulation of bacte.....
Document: CRV infection may contribute to sustained inflammation or activation of an inflammatory process that leads to irreversible airway damage, and can cause late airflow obstruction in SCT recipients. 31 Furthermore, CRV infections frequently coexist with bacterial or fungal pathogens, contributing to the development of pneumonia. It may be the result of epithelial damage, impaired ciliary function, an altered immune response, or upregulation of bacterial receptors on the CRV-infected respiratory tract. 16, 32 In addition, there have been several reports that SCT recipients have shown a lower immune response to the influenza vaccine compared with that observed for the general population. 33, 34 Severely immunocompromised patients, such as SCT recipients, have been reported to show prolonged influenza shedding, resulting in the development of antiviral resistance during prolonged antiviral therapy.
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