Selected article for: "different target protein and target protein"
Author: Noh, Heeju; Shoemaker, Jason E; Gunawan, Rudiyanto
Title: Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection
  • Document date: 2018_4_6
    • ID: j80hnhpb_40
    Snippet: The reference protein targets of compounds in drug treatment studies were compiled from five different public databases of chemical-protein interactions: DrugBank (44), Therapeutic Target Database (TTD) (45), MATADOR (46), Comparative Toxicogenomics Database (CTD) (47) , and STITCH (48) . DrugBank and TTD provided information on the mechanism of drug actions as well as the proteins that have physical binding interactions with drugs. Meanwhile, MA.....
    Document: The reference protein targets of compounds in drug treatment studies were compiled from five different public databases of chemical-protein interactions: DrugBank (44), Therapeutic Target Database (TTD) (45), MATADOR (46), Comparative Toxicogenomics Database (CTD) (47) , and STITCH (48) . DrugBank and TTD provided information on the mechanism of drug actions as well as the proteins that have physical binding interactions with drugs. Meanwhile, MATADOR, CTD, and STITCH gave interactions between proteins and chemical compounds, curated from text mining and experimental evidences. When retrieving the protein targets of drugs from these databases, we collected proteins that directly bind to the queried drugs. The reference targets for each dataset in this study are provided (49) , where 1292 host proteins that likely physically bind to viral proteins of influenza type A/WSN/33 in human embryonic kidney cells (HEK293) were identified by wholegenome co-immunoprecipitation assays.

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