Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-? Stimulated HaCaT Human Keratinocytes

Kang, Na-Jin; Koo, Dong-Hwan; Kang, Gyeoung-Jin; Han, Sang-Chul; Lee, Bang-Won; Koh, Young-Sang; Hyun, Jin-Won; Lee, Nam-Ho; Ko, Mi-Hee; Kang, Hee-Kyoung; Yoo, Eun-Sook

Biomol Ther 23 (3), 238-244 (2015) www.biomolther.org one of edible brown algae and is abundant along the coast of Jeju island. E. cava has been attended as a potential producer of diverse natural materials such as alginic acids, phlorotannins and fucoidans which show useful activities in bio-industrial areas including medicine, cosmetics, and functional foods (Wijesinghe et al., 2011; Kang et al., 2012b; Kim et al., 2014) . Phlorotannins (eckol, dieckol, and bieckol) isolated from E. species are representative components of marine secondary metabolites. Among them, dieckol is a phlorotannin compound consisting of a dimeric structure of polyphenolic compound eckol (Park et al., 2013) . Dieckol has shown anti-oxidant (Lee et al., 2012) , anti-cancer , anti-diabetic (Lee et al., 2012; Kang et al., 2013) , hepatoprotective (Kang et al., 2012a) , and anti-inflammatory effects (Yayeh et al., 2014) . There are several studies on the anti-inflammatory effects of dieckol in lipopolysaccharide (LPS)-induced murine macrophages (RAW264.7 cells) (Choi et al., 2014) . However, the biological effects of dieckol and its action mechanisms in skin inflammation including atopic dermatitis are poorly understood.