Author: Pruitt, Hawley C.; Devine, Daniel J.; Samant, Rajeev S.
Title: Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination Document date: 2016_3_11
ID: k3vjqumq_13
Snippet: Mutations which occur from defects in DNA damage repair pathways can lead to oncogenic insults that alter cell cycle progression. A number of studies have been conducted to assess the role of NMI on tumor cell growth. In vitro, NMI expression in GBM cell lines enhances cell proliferation by inhibiting G0/G1 cell cycle arrest and this effect was thought to be due to NMI binding with STAT1. 7 STAT1 blocks the cell cycle by transcriptionally up-regu.....
Document: Mutations which occur from defects in DNA damage repair pathways can lead to oncogenic insults that alter cell cycle progression. A number of studies have been conducted to assess the role of NMI on tumor cell growth. In vitro, NMI expression in GBM cell lines enhances cell proliferation by inhibiting G0/G1 cell cycle arrest and this effect was thought to be due to NMI binding with STAT1. 7 STAT1 blocks the cell cycle by transcriptionally up-regulating CDK inhibitors or by interacting directly with the Cyclin D1/CDK4 complex. 19, 20 In addition, NMI expression increased the growth rate of GBM xenografts. 7 NMI expression is significantly higher in GBM when compared to normal controls. 7 It is unclear whether NMI is causative in GBM progression or merely a bystander that serves as a prognostic indicator.
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