Selected article for: "action mechanism and cell line"
Author: Kang, Na-Jin; Koo, Dong-Hwan; Kang, Gyeoung-Jin; Han, Sang-Chul; Lee, Bang-Won; Koh, Young-Sang; Hyun, Jin-Won; Lee, Nam-Ho; Ko, Mi-Hee; Kang, Hee-Kyoung; Yoo, Eun-Sook
Title: Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-? Stimulated HaCaT Human Keratinocytes
  • Document date: 2015_5_1
    • ID: k6f3luil_32
    Snippet: Taken together, of the two phlorotannin compounds (eckol and dieckol) tested in this study, only dieckol strongly suppressed MDC production in HaCaT human keratinocytes. Dieckol also inhibited the activation of STAT1, a major transcription factor that activates the primary genes induced by IFN-γ. In addition, MAPKs pathway did not affect on the production of MDC in IFN-γ stimulated HaCaT cells. These results provide new evidence regarding anti-.....
    Document: Taken together, of the two phlorotannin compounds (eckol and dieckol) tested in this study, only dieckol strongly suppressed MDC production in HaCaT human keratinocytes. Dieckol also inhibited the activation of STAT1, a major transcription factor that activates the primary genes induced by IFN-γ. In addition, MAPKs pathway did not affect on the production of MDC in IFN-γ stimulated HaCaT cells. These results provide new evidence regarding anti-inflammatory potential of dieckol and its action mechanism in a skin cell line.

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