Author: Reperant, Leslie A.; MacKenzie, John; Osterhaus, Albert D.M.E.
Title: Periodic global One Health threats update Document date: 2015_12_4
ID: k7ocs5lz_19
Snippet: MERS-CoV was first identified as a novel zoonotic pathogen in late 2012 [19] . Since then, it has caused 1138 reported cases of zoonotic infection (Table 4) , with a case-fatality rate of about one-third. Infection is characterized in severe cases by symptoms of lower respiratory tract infection, respiratory distress, as well as renal failure [20] . MERS-CoV most likely originates from bat species, in which closely related viruses have been detec.....
Document: MERS-CoV was first identified as a novel zoonotic pathogen in late 2012 [19] . Since then, it has caused 1138 reported cases of zoonotic infection (Table 4) , with a case-fatality rate of about one-third. Infection is characterized in severe cases by symptoms of lower respiratory tract infection, respiratory distress, as well as renal failure [20] . MERS-CoV most likely originates from bat species, in which closely related viruses have been detected, causing chiefly asymptomatic infection [21, 22] . Dromedary camels, which develop mild respiratory tract infection with MERS-CoV, are increasingly recognized as the main proximate source of zoonotic infections [23, 24] . Contact with infected dromedary camels is considered the primary risk of infection in humans, while human-tohuman transmission remains rare. Nonetheless, secondary cases of MERS are increasingly reported, mainly in hospitalized settings, often with mild or no signs and symptoms.
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