Author: Xin Zeng; Lingfang Li; Jing Lin; Xinlei Li; Bin Liu; Yang Kong; Shunze Zeng; Jianhua Du; Huahong Xiao; Tao Zhang; Shelin Zhang; Jianghai Liu
Title: Blocking antibodies against SARS-CoV-2 RBD isolated from a phage display antibody library using a competitive biopanning strategy Document date: 2020_4_20
ID: 4w6caxwu_1
Snippet: The recent outbreak of a novel coronavirus disease (COVID-19) has emerged from a public health emergency of international concern to global pandemic. Its pathogen, SARS-CoV-2, is a newly identified β-coronavirus. Coronavirus got the family name from the spike(S) protein on the viral particle. The highly glycosylated S protein stays compact in trimeric state, recognizes receptor on the host cell membrane, and then undergoes a series of conformati.....
Document: The recent outbreak of a novel coronavirus disease (COVID-19) has emerged from a public health emergency of international concern to global pandemic. Its pathogen, SARS-CoV-2, is a newly identified β-coronavirus. Coronavirus got the family name from the spike(S) protein on the viral particle. The highly glycosylated S protein stays compact in trimeric state, recognizes receptor on the host cell membrane, and then undergoes a series of conformation changes, proteolysis events and membrane fusion to complete viral entry. For vaccines, clinical diagnosis, early prevention and medication, the S protein is the most significant target.
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