Author: Kang, Na-Jin; Koo, Dong-Hwan; Kang, Gyeoung-Jin; Han, Sang-Chul; Lee, Bang-Won; Koh, Young-Sang; Hyun, Jin-Won; Lee, Nam-Ho; Ko, Mi-Hee; Kang, Hee-Kyoung; Yoo, Eun-Sook
Title: Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-? Stimulated HaCaT Human Keratinocytes Document date: 2015_5_1
ID: k6f3luil_2
Snippet: IFN-γ, one of the multifunctional cytokines that have antiviral, anti-tumor, and immunomodulatory effects is produced predominantly in T cells and NK cells (Farrar and Schreiber, 1993) . Upon binding to IFN-γ, the IFN-γ receptor (IFN-γR1 and IFN-γR2) rapidly associates with the Janus tyrosine kinases JAK1 and JAK2. JAK1 and JAK2 phosphorylate one another and then subsequently phosphorylate the IFN-γ receptor, which leads to form a docking m.....
Document: IFN-γ, one of the multifunctional cytokines that have antiviral, anti-tumor, and immunomodulatory effects is produced predominantly in T cells and NK cells (Farrar and Schreiber, 1993) . Upon binding to IFN-γ, the IFN-γ receptor (IFN-γR1 and IFN-γR2) rapidly associates with the Janus tyrosine kinases JAK1 and JAK2. JAK1 and JAK2 phosphorylate one another and then subsequently phosphorylate the IFN-γ receptor, which leads to form a docking moiety for the cytoplasmic transcription factor named signal transducer and activator of transcription (STAT)1, a member of the STAT protein family (Ivashkiv and Hu, 2004; Best et al., 2005) . It has been found that STAT1 phosphorylation plays a critical role in IFN-mediated innate immunity to microbial infection, especially inflammatory responses (Ju et al., 2009) . It is also known that IFN-γ also stimulates the activation of p38 and extracellular signalregulated kinase 1/2 (ERK1/2), NF-κB (Pearson et al., 2001; Madonna et al., 2008) .
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