Author: Jain, K.K.
Title: Synthetic Biology and Personalized Medicine Document date: 2012_8_16
ID: jejgkcql_64
Snippet: Vaxign is the first web-based vaccine design system that predicts vaccine targets based on genome sequences using the strategy of RV. Predicted features in the Vaxign pipeline include protein subcellular location, transmembrane helices, adhesin probability, conservation to human and/ or mouse proteins, sequence exclusion from genome(s) of nonpathogenic strain(s) and epitope binding to MHC class I and class II. The precomputed Vaxign database cont.....
Document: Vaxign is the first web-based vaccine design system that predicts vaccine targets based on genome sequences using the strategy of RV. Predicted features in the Vaxign pipeline include protein subcellular location, transmembrane helices, adhesin probability, conservation to human and/ or mouse proteins, sequence exclusion from genome(s) of nonpathogenic strain(s) and epitope binding to MHC class I and class II. The precomputed Vaxign database contains prediction of vaccine targets for 1 70 genomes. Vaxign also performs dynamic vaccine target prediction based on input sequences. Vaccine candidates against E. coli were predicted using Vaxign and results indicate that Vaxign is an accurate and efficient vaccine design program [35] .
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