Author: Mammas, Ioannis N.; Greenough, Anne; Theodoridou, Maria; Kramvis, Anna; Rusan, Maria; Melidou, Angeliki; Korovessi, Paraskevi; Papaioannou, Georgia; Papatheodoropoulou, Alexia; Koutsaftiki, Chryssie; Liston, Maria; Sourvinos, George; Spandidos, Demetrios A.
Title: Paediatric Virology and its interaction between basic science and clinical practice (Review) Document date: 2018_1_4
ID: ix314s4n_36
Snippet: All patients with suspected cNS infection should undergo lumbar puncture (LP) unless this is contraindicated due to raised intracranial pressure. Investigations of cerebrospinal fluid (CSF) include the total and differential white cell count, red cell count, microscopy, culture, protein, glucose, lactate and a polymerase chain reaction (PCR) test for HSV-1 and HSV-2, VZV, enteroviruses and other possible pathogens depending on the clinical featur.....
Document: All patients with suspected cNS infection should undergo lumbar puncture (LP) unless this is contraindicated due to raised intracranial pressure. Investigations of cerebrospinal fluid (CSF) include the total and differential white cell count, red cell count, microscopy, culture, protein, glucose, lactate and a polymerase chain reaction (PCR) test for HSV-1 and HSV-2, VZV, enteroviruses and other possible pathogens depending on the clinical features (92, 93) . Neuroimaging, a CT scan or preferably MRI, should be performed as soon as possible. An MRI performed within 48 h of admission is abnormal in approximately 90% of patients, with some lesions being specific of certain aetiological factors (93) . An electroencephalogram (EEG) is considered if seizures are suspected.
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