2015 ACVIM Forum Research Abstract Program

In conclusion, normal dogs have an elliptical and saddleshaped annulus and an allometric relationship exists between MV size and BW. 3DTTE is a feasible and generally repeatable method for assessing the MV in normal dogs. The feasibility improved over time as a result of experience. The higher CV derived from measurement of two datasets from the same dog. Hypertrophic cardiomyopathy (HCM) is the most important feline heart disease and it is characterized by ventricular hypertrophy in absence of dilated left ventricle. In humans, the prevalence is 1 to 500 individuals and the familial HCM occurs in at least 60% of cases. There are more than 1400 mutations in more than 11 sarcomeres genes related to HCM. In some families of cats, HCM is an autosomal dominant genetic disease very similar to the human HCM. A mutation in myosin binding protein C gene (MYBPC3) is observed in Maine Coon cats with HCM. In Ragdoll cats, HCM is associated with a mutation in the same gene, but in a different codon highly conserved in feline species. In other breeds such as Persian, British Shorthair and Norwegian Forest there is also evidence of familial HCM, but the type of genetic inheritance is unknown. Persians cats presents high incidence of HCM and there are reports of familial hereditary component, but the mutation and the genetic inheritance have not been discovered yet.