2015 ACVIM Forum Research Abstract Program

The data was collected retrospectively from 198 dogs referred to one institution over a 15-year period with histopatologically confirmed or MRI consistent with meningioma. Dogs were grouped by anatomical site (supratentorial-E, infratentorial-T, spinal-S) and by therapeutic option (palliation-P, surgery-S, radiosurgery-R). The surgery goal was a total resection of tumour. LINAC based VMAT radiosurgery was performed in 1-5 fractions. Serial clinical and MRI examinations were conducted. Signalment, clinical signs, neuroanatomical tumour location, relapse specifics, adverse events, best response and overall survival (OS) time were evaluated. The OS estimates were calculated using the Kaplan-Meier method and the differences between compared groups using log-rank analysis. Multivariate analysis was performed using Cox regression. 91 dogs (51 E, 33 T, 7 S) had been palliated, 69 dogs (33 E, 31 T, 5 S) had been treated with stereotactic radio-surgery, 38 dogs (32 E, 1 T, 5 S) with surgery. OS in PE was 190 days, in PT 38 days, in PS 89 days, in RE 781 days, in RT 654 days, in RS 813 days, in SE 567 days, in ST 3 days, in SS 210 days. The predictive variables of OS are localisation and therapy option.