Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_247
Snippet: These data suggest that the ideal FDR in the cat lies between 2.5-5 mg/m 2 /min due to the maintenance of OPC for 2-4 hours. A follow up study evaluating gemcitabine in the cat using FDR of 2.5-5 mg/m 2 /min is recommended and currently underway. Metformin is used for management of non-insulin dependent diabetes mellitus in humans. Clinical evidence suggests patients taking metformin have a reduced lifetime incidence of cancer. Metformin's mechan.....
Document: These data suggest that the ideal FDR in the cat lies between 2.5-5 mg/m 2 /min due to the maintenance of OPC for 2-4 hours. A follow up study evaluating gemcitabine in the cat using FDR of 2.5-5 mg/m 2 /min is recommended and currently underway. Metformin is used for management of non-insulin dependent diabetes mellitus in humans. Clinical evidence suggests patients taking metformin have a reduced lifetime incidence of cancer. Metformin's mechanism of action is not understood, but may target AMP activated protein kinase (AMPK), which induces glucose uptake from blood into muscles. The upstream regulator of AMPK is LKB1, a well-recognized tumor suppressor. The study's purpose was to determine the pharmacokinetics and oral bioavailability of metformin to facilitate clinical trials evaluating metformin's effect in dogs with lymphoma.
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