Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_751
Snippet: Ten client-owned cats (1-7 years) with unremarkable CBC, chemistry and urinalyses were enrolled in a randomized doubleblind placebo-controlled three-way crossover study. Treatments consisted of 6 days of aural application of 7.5 mg/dose TM or placebo gel by owner, and 1.87 mg mirtazapine once orally in clinic (washout period: 7 days). Owners documented appetite, rate of food ingestion, begging, activity and vocalization daily in the home environm.....
Document: Ten client-owned cats (1-7 years) with unremarkable CBC, chemistry and urinalyses were enrolled in a randomized doubleblind placebo-controlled three-way crossover study. Treatments consisted of 6 days of aural application of 7.5 mg/dose TM or placebo gel by owner, and 1.87 mg mirtazapine once orally in clinic (washout period: 7 days). Owners documented appetite, rate of food ingestion, begging, activity and vocalization daily in the home environment. On day 6 cats were observed for 8 hours in hospital; food consumed, activity and vocalization was documented hourly and trough and peak serum levels were obtained. Serum alanine aminotransferase (ALT) levels were measured after TM administration. Serum mirtazapine and compounded gel concentrations were measured using liquid chromatography/ tandem mass spectrometry.
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