Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_841
Snippet: Immunohistochemical staining for MHC class I, II, CD3+, CD4+, CD8+, and CD20+ lymphocytes was performed on muscle samples from 18 Quarter Horses with a history of recent muscle atrophy. The degree of lymphocyte infiltration in muscle or around vessels was scored for each lymphocyte subtype. Sarcolemmal MHC expression was detected in all muscle biopsies with a majority (n = 14) of horses having more MHC class I than II expression. A strong positiv.....
Document: Immunohistochemical staining for MHC class I, II, CD3+, CD4+, CD8+, and CD20+ lymphocytes was performed on muscle samples from 18 Quarter Horses with a history of recent muscle atrophy. The degree of lymphocyte infiltration in muscle or around vessels was scored for each lymphocyte subtype. Sarcolemmal MHC expression was detected in all muscle biopsies with a majority (n = 14) of horses having more MHC class I than II expression. A strong positive correlation occurred between MHC class I and II expression (r 2 = 0.62). Scores for all lymphocyte subtypes infiltrating myocytes significantly correlated with MHC I and II expression (range r 2 0.24-0.51: P < 0.05). In 11/18 horses, CD4+ rather than CD8+ lymphocytes predominated.
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