Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_250
Snippet: The general disposition pattern of metformin in dogs is similar to that reported in cats and humans. Development of secondary high-grade lymphoma from indolent lymphoid malignancies has been reported in humans, commonly referred to Richter's syndrome. Similar conditions have been also reported in dogs. Recently, we have constructed a new GeneScan analytical system using multicolorlabeled primers and capillary electrophoresis to detect the rearran.....
Document: The general disposition pattern of metformin in dogs is similar to that reported in cats and humans. Development of secondary high-grade lymphoma from indolent lymphoid malignancies has been reported in humans, commonly referred to Richter's syndrome. Similar conditions have been also reported in dogs. Recently, we have constructed a new GeneScan analytical system using multicolorlabeled primers and capillary electrophoresis to detect the rearrangement of immunoglobulin heavy chain (IgH) and Tcell receptor gamma chain (TCRc) genes in dogs. Herein, we used this GeneScan analysis to differentiate the clonal origin of cells in dogs that developed two different types of lymphoid malignancies.
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