Selected article for: "AIP mutation and aryl hydrocarbon receptor"
Title: 2015 ACVIM Forum Research Abstract Program
  • Document date: 2015_5_27
    • ID: 3pnuj5ru_267
    Snippet: Exon 1 encodes for a region of the AIP protein considered essential for AIP-AIP receptor interaction. Although 70 different human mutations have been identified to date, a human AIP: c9G>T mutation has not yet been identified. The AIP N-terminal is required for the stability of the AIP protein -AhR-receptor complex, and essential for the regulation of translocation into the nucleus, where it binds to aryl hydrocarbon receptor nuclear translocator.....
    Document: Exon 1 encodes for a region of the AIP protein considered essential for AIP-AIP receptor interaction. Although 70 different human mutations have been identified to date, a human AIP: c9G>T mutation has not yet been identified. The AIP N-terminal is required for the stability of the AIP protein -AhR-receptor complex, and essential for the regulation of translocation into the nucleus, where it binds to aryl hydrocarbon receptor nuclear translocator leading to activation of genes thought to act as tumour suppressors. Loss of normal AIP activity is thought to promote somatotrophinoma development. It is possible that the AIP:c.9G>T mutation predisposed to somatrotrophinoma tumourigensis in the two affected patients, and a study containing larger numbers of acromegalic and control cases would improve our understanding of the AIP:c.9G>T SNP.

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