2015 ACVIM Forum Research Abstract Program

Newly diagnosed non-azotemic hyperthyroid cats (plasma total thyroxine (TT4)>55 nmol/l) and a group of healthy (control), non-azotemic, euthyroid (TT4 < 40 nmol/l), non proteinuric (urine protein: creatinine ratio <0.4), geriatric (>9 years old) cats were recruited from five UK first opinion practices. Hyperthyroid cats were monitored for the development of renal azotemia (defined as plasma creatinine concentration >2 mg/dl with urine specific gravity <1.035) during a four month period following restoration of euthyroidism (TT4 10-40 nmol/l). Agarose gel SPE was performed to calculate the serum concentrations of albumin, a 1 , a 2 , b and c globulins. Non-parametric statistics were used to compare baseline serum concentrations of a 1 , a 2 , b, c and total globulin between hyperthyroid and control cats, between hyperthyroid cats which developed azotemia in the follow up period (pre-azotemic) and those which remained non-azotemic (at baseline), and in hyperthyroid cats before and after restoration of euthyroidism. Data are presented as median [25 th , 75 th percentile] and statistical significance was defined as P < 0.05.