2015 ACVIM Forum Research Abstract Program

After administration of the products time to maximum DCA concentration was 12 hour for CCFA and 1 hour for ceftiofur sodium. Maximum plasma DCA concentration was significantly higher for calves given ceftiofur sodium (5.62 lg/mL) than for calves given CCFA (3.23 lg/mL). AUC 0-∞ and Vd/F were significantly greater for calves given CCFA than for calves given ceftiofur sodium. The terminal half-life of DCA in plasma was significantly longer for calves given CCFA (60.6 hour) than calves for calves given ceftiofur sodium (18.1 hour). Cl/F was not significantly different between groups. The duration of time median plasma DCA concentrations remained above above 2.0 lg/ mL was significantly longer in calves that received CCFA (84.6 hour) as compared to calves that received ceftiofur sodium (21.7 hour).