Selected article for: "antiviral activity and high affinity"
Author: Ross D. Overacker; Somdev Banerjee; George F. Neuhaus; Selena Milicevic Sephton; Alexander Herrmann; James A. Strother; Ruth Brack-Werner; Paul R. Blakemore; Sandra Loesgen
Title: Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline
  • Document date: 2019_1_23
    • ID: m2zw8eq4_24
    Snippet: HIV-1 integrase inhibitor showed no binding at any concentration tested as expected (SI Figure 265 4). Although the acquired KD of 38 µM associated with B#24 is higher than the IC50 in cell-based 266 assays, it should be noted that the affinity value cannot be directly related to neutralization 267 efficacy, as seen in many high-affinity, non-neutralizing HIV antibodies. [55] [56] [57] No binding was 268 observed for the related azaBINOLs of in.....
    Document: HIV-1 integrase inhibitor showed no binding at any concentration tested as expected (SI Figure 265 4). Although the acquired KD of 38 µM associated with B#24 is higher than the IC50 in cell-based 266 assays, it should be noted that the affinity value cannot be directly related to neutralization 267 efficacy, as seen in many high-affinity, non-neutralizing HIV antibodies. [55] [56] [57] No binding was 268 observed for the related azaBINOLs of interest from the compound library (SI Figure 7) . In 269 summary, the BLI binding data obtained reveals a striking correlation between the binding 270 affinity of B#24 towards its target HIV RT and its antiviral activity. 271

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