2015 ACVIM Forum Research Abstract Program

Significant and severe fibrosis were predicted by logistic regression using 4 biological parameters. According to Metavir score, the prevalence of diagnostic targets in this selected population was: significant fibrosis: 40.1%, severe fibrosis: 25.7%. The AU-ROC curve of derived score probability was respectively 0.73 (Se = 0.80; Sp = 0.65) and 0.91 (Se = 0.89; Sp = 0.88) This study shows an interesting correlation between non-invasive methods and liver fibrosis in ST. However no single marker is ideal to predict fibrosis and a combination of several markers might be helpful to offer a diagnostic test for liver fibrosis with acceptable sensitivity and specificity. Canine immune-mediated thrombocytopenia (ITP) and immune-mediated hemolytic anemia (IMHA) are associated with high morbidity and risk of mortality. Thymidine kinase (TK), an enzyme important for DNA synthesis and cell division, may correlate with uncontrolled replication or regeneration following destruction. Canine C-reactive protein (c-CRP) has been used as an inflammatory disease biomarker. 25-Hydroxyvitamin D (25 (OH)D) is involved in innate and adaptive immunity with hypovitaminosis D associated with increased incidence of autoimmune disease in humans. We hypothesized that plasma TK and c-CRP would be significantly higher in dogs with poorly-versus wellcontrolled ITP and IMHA and that these dogs would be vitamin D insufficient.