2015 ACVIM Forum Research Abstract Program

The present study shows that splenitis is an uncommon disorder in dogs. Splenitis is frequently secondary to inflammation of other organs or to systemic infections, although in numerous dogs it may not be associated with other obvious diseases. Prog-nosis is favourable in the majority of affected dogs. Several histological patterns of inflammation are identified in dogs with splenitis but whether they reflect different causes deserves further studies. PCR may not be a sensitive tool to detect bacteria and fungi DNA in formalin-fixed, paraffin-embedded splenic samples. Cyniclomyces guttulatus is a commensal yeast of the rodent and rabbit gastrointestinal tract and is infrequently described in dog fecal samples. The environmental source of C. guttulatus in dogs is unclear, however it is frequently presumed that dogs diagnosed with C. guttulatus have ingested rabbit feces. This study aimed to conduct a comparative sequence analysis of a fragment of the large subunit (26S) rDNA variable D1/D2 domain of C. guttulatus from dogs, pet rabbits, and laboratory rabbits to elucidate if different genotypes are affecting each species.