Selected article for: "good agreement and significant association"
Title: 2016 ACVIM Forum Research Abstract Program
  • Document date: 2016_5_31
    • ID: 2y1y8jpx_304
    Snippet: The number of pANCA or cANCA positive results in the group of FRD dogs was 27/44 (61%). To the contrary, none of the dogs in the SRD group had evidence of pANCA or cANCA seroreactivity (0/20). Consequently, sensitivity of the new assay to predict FRD amongst a group of dogs with chronic enteropathies was 0.61 (95% CI 0.45-0.75); and specificity was 1.0 (95% CI 0.89-1.0). This is comparable to previous studies using the canine granulocyte method (.....
    Document: The number of pANCA or cANCA positive results in the group of FRD dogs was 27/44 (61%). To the contrary, none of the dogs in the SRD group had evidence of pANCA or cANCA seroreactivity (0/20). Consequently, sensitivity of the new assay to predict FRD amongst a group of dogs with chronic enteropathies was 0.61 (95% CI 0.45-0.75); and specificity was 1.0 (95% CI 0.89-1.0). This is comparable to previous studies using the canine granulocyte method (sensitivity 0.51; specificity 0.95). Fishers exact test revealed a statistically significant association of a positive pANCA or cANCA test with FRD (P < 0.0001). Inter-observer agreement for the assay was good (kappa 0.75). Furthermore, in 8 of the ANCA positive cases, it was possible to identify either MPO or PR-3 as antigens on the biochips.

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