2015 ACVIM Forum Research Abstract Program

In dogs with HAC, the odds of AP were 4.55 times that of dogs without HAC, and in dogs with DM, the odds were 12.44 times that of dogs without DM. In addition, there was a significant association between the presence of DM and hyperlipidemia in the AP group. This study showed that hyperlipidemia caused by DM was associated with AP in dogs, but an association was not observed between HAC and hyperlipidemia in dogs with AP. However, further study will be necessary to clarify the prevalence of AP in dogs with DM and HAC. Dysregulation of adipokines has been described in humans with cardiovascular disease, but information is lacking on concentrations of circulating adipokines in dogs with myxomatous mitral valve disease (MMVD). The objective of this case-controlled observational study was to determine whether serum adipokine concentrations differed between healthy dogs and dogs with MMVD. Initially, a preliminary study was performed on 21 client-owned dogs with MMVD and 30 healthy dogs with the same body condition score, and several adipokines were measured. Based on the preliminary results, serum leptin and adiponectin concentrations were re-evaluated in 46 dogs newlydiagnosed with MMVD which were divided into 3 groups according to the International Small Animal Cardiac Health Council (ISACHC) classification.