Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_640
Snippet: PK: Dolasetron was quickly metabolized to hydrodolasetron with only two cats in each administration route having measurable concentrations beyond 2 hours, limiting the assessment of dolasetron PK parameters. There was no significant difference in exposure to the active metabolite between the two routes of administration. Pharmacokinetic parameters are summarized below. PD: When dolasetron or placebo was administered prior to xylazine, there was n.....
Document: PK: Dolasetron was quickly metabolized to hydrodolasetron with only two cats in each administration route having measurable concentrations beyond 2 hours, limiting the assessment of dolasetron PK parameters. There was no significant difference in exposure to the active metabolite between the two routes of administration. Pharmacokinetic parameters are summarized below. PD: When dolasetron or placebo was administered prior to xylazine, there was no significant difference in the mean number of emetic events, lip licks, time to onset of vomiting or visual nausea score when compared to placebo.
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