Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_676
Snippet: Three horses were included in a safety study testing administration of intravenous dofetilide (8.0 µg/kg BWT), ranolazine (2.4 mg/kg BWT) and a combination of the two using similar doses. The horses were monitored clinically for adverse reactions and Holter monitor ECG recordings, as well as blood pressure measurements, were obtained throughout the study. Following the safety study, nine horses were included in an electrophysiological study test.....
Document: Three horses were included in a safety study testing administration of intravenous dofetilide (8.0 µg/kg BWT), ranolazine (2.4 mg/kg BWT) and a combination of the two using similar doses. The horses were monitored clinically for adverse reactions and Holter monitor ECG recordings, as well as blood pressure measurements, were obtained throughout the study. Following the safety study, nine horses were included in an electrophysiological study testing the effects of dofetilide and ranolazine on electrical induced AF. By placing two intraatrial electrodes we were able to record atrial electrograms and perform atrial pacing for measurements of atrial effective refractory periods (aERPs) and induction of AF. All horses went through four procedures (dofetilide and ranolazine respectively, combination of the two drugs using lower dosages and a control procedure where only saline was administered) with 7 days wash out periods between treatments.
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