2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Comparable milk discard times were generated from all methods, which suggested a longer milk discard time is necessary for this cohort of cows with mastitis. The prediction of the population method was sensitive to the range of milk production volume selected for the simulation. This novel method utilized all available data, including data below the assay quantification limit. The study demonstrated the viability of a population physiologically-based model for estimation of milk discard times. Augmenting innate mucosal defense mechanisms with iodine is effective at killing bovine bacterial and viral respiratory pathogens in vitro and could be a valuable preventative strategy against respiratory disease in dairy calves. The objective of this study was to determine the kinetics of iodine in nasal secretions following oral administration of 20mg/kg inorganic iodine (NaI), in order to assess the feasibility of using NaI to prevent bovine respiratory disease in vivo.