Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_371
Snippet: Hirotaka Igarashi 1 , Keisuke Konishi 2 , Eri Uchida 3 , Takashi Tamamoto The expression levels of all tested genes, with the exception of IL-4, were significantly up-regulated in the polypoid lesion. When the rate of increase in the expression of each gene was compared, the rates of increase of IL-1β, IL-6, IL-8, and IL-17 were significantly higher than that of IL-10, whereas the rates of increase of IFN-γ and TNF-α were significantly lower t.....
Document: Hirotaka Igarashi 1 , Keisuke Konishi 2 , Eri Uchida 3 , Takashi Tamamoto The expression levels of all tested genes, with the exception of IL-4, were significantly up-regulated in the polypoid lesion. When the rate of increase in the expression of each gene was compared, the rates of increase of IL-1β, IL-6, IL-8, and IL-17 were significantly higher than that of IL-10, whereas the rates of increase of IFN-γ and TNF-α were significantly lower than that of IL-10. The number of Tregs in the polypoid lesion was significantly increased compared to that in the noninflamed colonic mucosa of ICRP-affected MDs and control dogs. The number of macrophages was not significantly different between the groups. There was a significant positive correlation between the expression level of IL-10 gene and that of Foxp3 gene (r = 0.749, P < 0.001). In addition, a significant positive correlation was observed between the expression level of IL-10 gene and the number of Tregs (r = 0.527, P < 0.01).
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