Author: McWhirter, Sarah M.; Barbalat, Roman; Monroe, Kathryn M.; Fontana, Mary F.; Hyodo, Mamoru; Joncker, Nathalie T.; Ishii, Ken J.; Akira, Shizuo; Colonna, Marco; Chen, Zhijian J.; Fitzgerald, Katherine A.; Hayakawa, Yoshihiro; Vance, Russell E.
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP Document date: 2009_8_31
ID: 3b8b8p61_46
Snippet: Mice and cell lines. Bone marrow macrophages were derived from various mouse strains, including Mavs / (Sun et al., 2006) , Mda5 / (Gitlin et al., 2006) , and Zbp1 / (Ishii et al., 2008) . Wild-type C57BL/6 and Tnfr1 / mice were from the Jackson Laboratory. Myd88 / /Trif / mice were obtained from G. Barton (University of California, Berkeley, Berkeley, CA). Irf1 / , Irf3 / , Irf5 / , and Irf 7.....
Document: Mice and cell lines. Bone marrow macrophages were derived from various mouse strains, including Mavs / (Sun et al., 2006) , Mda5 / (Gitlin et al., 2006) , and Zbp1 / (Ishii et al., 2008) . Wild-type C57BL/6 and Tnfr1 / mice were from the Jackson Laboratory. Myd88 / /Trif / mice were obtained from G. Barton (University of California, Berkeley, Berkeley, CA). Irf1 / , Irf3 / , Irf5 / , and Irf 7 / mice were obtained from T. Taniguchi (University of Tokyo, Tokyo, Japan). Tbk1 / /Tnfr1 / mice were generated by crossing Tbk1 / mice (provided by W.-C. Yeh, University of Toronto, Toronto, Canada) with Tnfr1 / mice. Rip2 / mice were obtained from R. Medzhitov (Yale University, New Haven, CT). Nod1 / /Nod2 / mice were obtained from D. Portnoy (University of California, Berkeley, Berkeley, CA). Nalp3 / mice were obtained from V. Dixit (Genentech, South San Francisco, CA). ISRE-L929 IFN reporter cells were obtained from
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