Selected article for: "capture sample and viral read"
Author: Hayden C. Metsky; Katherine J. Siddle; Adrianne Gladden-Young; James Qu; David K. Yang; Patrick Brehio; Andrew Goldfarb; Anne Piantadosi; Shirlee Wohl; Amber Carter; Aaron E. Lin; Kayla G. Barnes; Damien C. Tully; Björn Corleis; Scott Hennigan; Giselle Barbosa-Lima; Yasmine R. Vieira; Lauren M. Paul; Amanda L. Tan; Kimberly F. Garcia; Leda A. Parham; Ikponmwonsa Odia; Philomena Eromon; Onikepe A. Folarin; Augustine Goba; Etienne Simon-Lorière; Lisa Hensley; Angel Balmaseda; Eva Harris; Douglas Kwon; Todd M. Allen; Jonathan A. Runstadler; Sandra Smole; Fernando A. Bozza; Thiago M. L. Souza; Sharon Isern; Scott F. Michael; Ivette Lorenzana; Lee Gehrke; Irene Bosch; Gregory Ebel; Donald Grant; Christian Happi; Daniel J. Park; Andreas Gnirke; Pardis C. Sabeti; Christian B. Matranga
Title: Capturing diverse microbial sequence with comprehensive and scalable probe design
  • Document date: 2018_3_12
    • ID: a9lkhayg_13
    Snippet: We first assessed enrichment of viral content by examining the change in per-base read depth resulting from capture with V ALL . Overall, we observed a median increase in unique viral reads across all samples of 18× (Q 1 = 4.6, Q 3 = 29.6) (Supplementary Table 3 ). Capture increased depth across the length of each viral genome, with no apparent preference in enrichment for regions over this length (Fig. 2a, b, Supplementary Fig. 4) . Moreover, c.....
    Document: We first assessed enrichment of viral content by examining the change in per-base read depth resulting from capture with V ALL . Overall, we observed a median increase in unique viral reads across all samples of 18× (Q 1 = 4.6, Q 3 = 29.6) (Supplementary Table 3 ). Capture increased depth across the length of each viral genome, with no apparent preference in enrichment for regions over this length (Fig. 2a, b, Supplementary Fig. 4) . Moreover, capture successfully enriched viral content in each of the 6 sample types we tested. The increase in coverage depth varied between samples, likely in part because the samples differed in their starting concentration and, as expected, we saw lower enrichment in samples with higher abundance of virus before capture ( Supplementary Fig. 5 ).

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