Selected article for: "cell membrane and Ebola virus"
Author: Xia, Shuai; Yan, Lei; Xu, Wei; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien-Te K.; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, Ian A.; Jiang, Shibo; Yang, Bei; Lu, Lu
Title: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike
  • Document date: 2019_4_10
    • ID: 3c5ab73l_14
    Snippet: Blam-Vpr assay is a sensitive model to characterize the inhibitory mechanism and activity of antiviral agents on virus-cell membrane fusion. This assay has been widely used for assessing the membrane fusion activity of various viruses, including HIV-1, Ebola virus, and henipavirus (34) (35) (36) (37) . Here, we developed the Blam-Vpr assays for MERS-CoV and SARS-CoV to further clarify the fusion inhibitory mechanism of EK1. We found that EK1 effe.....
    Document: Blam-Vpr assay is a sensitive model to characterize the inhibitory mechanism and activity of antiviral agents on virus-cell membrane fusion. This assay has been widely used for assessing the membrane fusion activity of various viruses, including HIV-1, Ebola virus, and henipavirus (34) (35) (36) (37) . Here, we developed the Blam-Vpr assays for MERS-CoV and SARS-CoV to further clarify the fusion inhibitory mechanism of EK1. We found that EK1 effectively inhibited the entry of MERS-CoV Blam-Vpr virions and SARS-CoV Blam-Vpr virions into Huh-7 cells and ACE2-293 T cells, respectively, in a dose-dependent manner ( fig. S2D ), thus confirming that EK1 does act as an HCoV fusion inhibitor.

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