Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_228
Snippet: Results: Hedgehog pathway mediators, including IHH, GLI1, GLI2 and PTCH1, were found to be expressed in 5 canine transitional cell carcinoma cell lines. Indian Hedgehog was expressed in 5-25% of tumor cells in 5 canine bladder tumor tissues, but not in normal canine bladder tissue. Inhibition of Hedgehog signaling with cyclopamine and GANT61, confirmed by decreased expression of downstream target genes, led to significantly decreased cell prolife.....
Document: Results: Hedgehog pathway mediators, including IHH, GLI1, GLI2 and PTCH1, were found to be expressed in 5 canine transitional cell carcinoma cell lines. Indian Hedgehog was expressed in 5-25% of tumor cells in 5 canine bladder tumor tissues, but not in normal canine bladder tissue. Inhibition of Hedgehog signaling with cyclopamine and GANT61, confirmed by decreased expression of downstream target genes, led to significantly decreased cell proliferation but had a lesser effect on apoptosis.
Search related documents:
Co phrase search for related documents- cell carcinoma and decrease expression: 1
- cell carcinoma and less effect: 1, 2
- cell carcinoma and significantly decrease: 1
- cell line and decrease expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell line and downstream target gene: 1, 2
- cell line and less effect: 1
- cell proliferation and decrease expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cell proliferation and downstream target gene: 1, 2, 3
- cell proliferation and less effect: 1, 2
Co phrase search for related documents, hyperlinks ordered by date