2015 ACVIM Forum Research Abstract Program

For this purpose, were included in the study 8 bitches with mammary tumors submitted to UTM and 8 to UTM associated to OSH. Venous blood samples were taken preoperatively (M0), at the end of surgery (M1), 3 hours (M2), 6 hours (M3), 24 hours (M4), 72 hours (M5) and 10 days postoperatively, for serum IL-2 and IL-6 levels. Data were logarithmically transformed and then submitted to Friedman test for differences between moments within the group and Mann Whitney test for moments between groups. There was no significant difference between moments or groups in any of the studied parameters. Results are summarized in Table 1 . Under the conditions of this study and based on the observed results it can be concluded that UTM alone or in association with OSH does not induce significant changes in serum levels of IL-2 and IL-6 in the postoperative period. Increased secretion of pituitary hormones, activation of the sympathetic nervous system and the release of cytokines and acute phase proteins are the main metabolic changes associated with surgical trauma. The intensity of the organic response depends on the magnitude, duration and nature of the stimuli. Minor surgery commonly induces smaller responses compared to medium and large procedures. Excessive release of hormones and humoral mediators after surgical trauma may be responsible for multiple adverse events in the postoperative period, included high protein catabolism, metabolic acidosis, blood hypercoagulability, interstitial edema, immune depression and delayed healing. Given the lack of related studies evaluating the metabolic response associated with mastectomy in dogs, the aim of this study was to evaluate the serum concentration of cortisol, glucose and albumin in the perioperative period of unilateral total mastectomy (UTM) alone or in association with ovariosalpingohisterectomy (OSH) in bitches with mammary tumors.