2015 ACVIM Forum Research Abstract Program

Marco 1 , Thais Grunho 2 , Chen Gilor 3 . 1 University of Santo Amaro/Naya Especialidades, São Paulo, SP, Brazil, 2 University of Santo Amaro, São Paulo, SP, Brazil, 3 The Ohio State University, Columbus, OH, USA Day-to-day variability of serial blood glucose curves (BGC) impedes balancing control of clinical signs and avoidance of hypoglycemia in diabetics. Day-to-day variability differs between insulin formulations but was previously reported only for porcine lente in dogs. Here we report on the day-to-day variability of BGC in well controlled (based on stable clinical signs including body weight) dogs treated with human-recombinant NPH (n = 5) or insulin detemir (n = 3). In each dog, four successive 12-h BGC's were performed at home by the owners, during no more than a 28 days period. Insulin dose and meals (including quantities, type, time of administration etc.) as well as blood sampling times remained unchanged throughout this time period. Recorded BG parameters included: BG obtained just prior to insulin injections (BG fast 0 , BG fast 12), maximum (BG max ), minimum (Nadir), mean (BG mean ) and Delta [BG fast 0-Nadir]. Day-to-day variability was calculated as previously described (Fleeman & Rand, JAV-MA 2003) except that for each dog, for each parameter, the 2 most extreme values (out of the 4 BGC's) were used to calculate maximal differences (Delta max ). For each parameter, the mean AE sd and CV (CV=SD/mean) of Delta max were calculated for all dogs in each insulin group and presented below. In conclusion, for each parameter, mean maximal differences were smaller between BGC's in the detemir group compared to the NPH group, suggesting overall lesser day-to-day variation in insulin action and greater confidence when interpreting the results of BGC's.