Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_397
Snippet: When compared to immediate post-eradication samples GKN gene expression is up-regulated in the presence of Helicobacter spp. in dogs without evidence for concurrent inflammation. Further evaluation is required to identify the relevance of this finding, however given a suspected role in gastric homeostasis, upregulation could contribute to limit development of gastritis in Helicobacter spp positive dogs. Accumulating evidence has shown a significa.....
Document: When compared to immediate post-eradication samples GKN gene expression is up-regulated in the presence of Helicobacter spp. in dogs without evidence for concurrent inflammation. Further evaluation is required to identify the relevance of this finding, however given a suspected role in gastric homeostasis, upregulation could contribute to limit development of gastritis in Helicobacter spp positive dogs. Accumulating evidence has shown a significant relationship between the gastrointestinal (GI) microbiota and host GI health. Microbial metabolites are believed to play a critical role in hostmicrobial interactions. Short-chain fatty acids are major endproducts of bacterial carbohydrate fermentation in the intestinal tract. They constitute an important energy source for intestinal epithelial cells and help maintain intestinal mucosal integrity. Decreased concentrations of short-chain fatty acids have been observed in humans with GI disease. However, large scale clinical data are lacking in small animal medicine. Therefore, the aim of this study was to evaluate fecal concentrations of short-chain fatty acids in healthy pet dogs and dogs with chronic enteropathy.
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