Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin Document date: 2020_4_9
ID: eksi9yia_42
Snippet: The expression of the P. alecto tetherin isoforms A, B, and C, and M. macropus tetherin A and B, reveals differences in their relative capacities to form homodimers under our assay conditions (Figure 7 ). This observation is notable because the capacity of tetherin to form cysteine-linked dimers is required for the restriction of HIV-1 viral particles (46) which we chose as the VLPs against which bat tetherin proteins were functionally validated .....
Document: The expression of the P. alecto tetherin isoforms A, B, and C, and M. macropus tetherin A and B, reveals differences in their relative capacities to form homodimers under our assay conditions (Figure 7 ). This observation is notable because the capacity of tetherin to form cysteine-linked dimers is required for the restriction of HIV-1 viral particles (46) which we chose as the VLPs against which bat tetherin proteins were functionally validated for inhibiting viral particle release. In contrast to restriction of HIV-1, Sakuma et al. (49) have reported that tetherin dimerisation is not required for the restriction of arenaviruses and filoviruses, suggesting that the need for dimerisation is virus/VLP-dependent.
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