2015 ACVIM Forum Research Abstract Program

Thirty-two cats (16 neutered males, 16 females) were divided into four treatment groups including four animals of each sex per group. The cats were acclimated to the study environment for 10 days prior to study start. All cats were orally dosed with placebo (Group 1) or capromorelin (30 mg/mL oral solution) at 1 mg/kg (Group 2), 2 mg/kg (Group 3) or 3 mg/kg (Group 4), for 21 days, with dosing starting on Day 1. Physical examinations were performed on Day À10 and general health observations made daily. Body weights were evaluated on Days -10, À8, À1, 1, 8, 15 and 22 days. Cats were fed approximately 1 hour after dosing; 300 g of commercial dry cat food was provided for 5 hours and then removed and the amount of food consumed (g) calculated per cat. On Days 1, 14 and 21, blood samples were collected prior to daily dose administration and 8 hours postdose and serum processed for measurement of IGF-1 levels. On Day 12, two study animals (one male each from Groups 1 and 4) were removed for reasons unrelated to the study and were not included in the data analysis.