2015 ACVIM Forum Research Abstract Program

Serum ibuprofen concentration reduction was less than expected (65 -70%), which we attribute to sequestration of drug into red blood cells. Nonetheless, the results suggest TPE may be used to rapidly reduce ibuprofen concentration following acute toxic ingestion. Medical records of all dogs hospitalized for SP between 2004 and 2014 were reviewed. Inclusion criteria required a CBC, serum chemistry, and NOVA at admission. Diagnosis of SP was based on intracellular bacteria and/or positive culture of abdominal fluid. APPLE scores were calculated for all patients. Data was checked for normality using a Shapiro-Wilk and D'Agostino & Pearson omnibus tests. Parametric and non-parametric data were compared using an unpaired t-test and a Mann-Whitney test, respectively. Fisher's exact test and Odds ratios were constructed to compare proportions between variables with categorical data. Alpha was set at 0.05 Fifty-four dogs met inclusion criteria and had a survival rate of 64.8%. Gastrointestinal origin of SP comprised 62.9% of cases. E.coli and Enterococcus species comprised 60% of bacterial isolates. There was no difference in the median circulating neutrophil count (12,193 vs. 7140/lL; P = 0.19), total WBC count (16.9 vs. 13.8 9 10 9 /L; P = 0.20), time to surgery (8.0 vs. 6.0 hour; P = 0.30), and APPLE (full) score (35.0 vs 37.5; P = 0.06) between survivors and non-survivors. Exact testing revealed no association between the presence of Dohle bodies (P = 0.53), toxic changes (P = 0.24), band neutrophils (P = 0.08), ionized hypocalcemia (<1.23 mmol/L; P = 0.72), or ionized hypomagnesemia (<0.38 mmol/L; (P = 0.26). Appropriate initial antibiotic therapy was not associated with survival (P = 0.24); however, dogs that received appropriate antibiotics were 2.36 times more likely to survive. Initial antibiotic choice was only appropriate in 39% of cases. The mean APPLE (fast) score was the only factor associated with death (24.5 vs 29.3; P < 0.01).