Author: Draz, Mohamed Shehata; Shafiee, Hadi
Title: Applications of gold nanoparticles in virus detection Document date: 2018_2_15
ID: 1xjmlwqr_43
Snippet: A very interesting AuNP-based molecular assay has been developed for the bimodal scanometric and SERS-based detection of EBOV by using AuNPs to promote silver staining on their large surface area [50] . The target EBOV DNA sequence is first captured on chip surfaces by specific, short DNA probes and labeled with AuNP-DNA-Cy3 probes. Then, the formed 3-component hybridization complexes are subjected to a silver enhancement step. The deposited silv.....
Document: A very interesting AuNP-based molecular assay has been developed for the bimodal scanometric and SERS-based detection of EBOV by using AuNPs to promote silver staining on their large surface area [50] . The target EBOV DNA sequence is first captured on chip surfaces by specific, short DNA probes and labeled with AuNP-DNA-Cy3 probes. Then, the formed 3-component hybridization complexes are subjected to a silver enhancement step. The deposited silver metal eventually enables scanometric detection (based on a silver-caused dark color) and SERS detection (based on using Cy3 as a Raman-active tag) (Fig. 6) .
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