Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_343
Snippet: As with dogs, there appears to be an absence of a significant correlation between histologic severity and clinical scorings such as a clinical severity index or fecal score in cats with chronic enteropathy. A significant correlation was, however, identified between a novel set of IHC markers and both the histopathology and clinical severity scores. The pathophysiologic relevance and clinical utility of these markers remains to be determined. Exoc.....
Document: As with dogs, there appears to be an absence of a significant correlation between histologic severity and clinical scorings such as a clinical severity index or fecal score in cats with chronic enteropathy. A significant correlation was, however, identified between a novel set of IHC markers and both the histopathology and clinical severity scores. The pathophysiologic relevance and clinical utility of these markers remains to be determined. Exocrine pancreatic insufficiency (EPI) in dogs is characterized by maldigestion as a result of inadequate synthesis and secretion of pancreatic enzymes. Previous studies have shown that dogs with EPI have small intestinal dysbiosis (SID) and may require concurrent antibiotic therapy in addition to pancreatic enzyme replacement therapy. In humans, patients with short bowel syndrome, which is also characterized by maldigestion and SID, have been reported to have increased fecal lactate concentrations. Therefore, the aim of this study was to compare the abundance of lactic acid-producing bacteria and D-and L-lactate concentrations in feces from healthy dogs (n = 18), dogs undergoing enzyme replacement therapy for EPI (n = 17), and untreated dogs with EPI (n = 5).
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