Selected article for: "different dose and drug administration"
Title: 2016 ACVIM Forum Research Abstract Program
  • Document date: 2016_5_31
    • ID: 2y1y8jpx_368
    Snippet: Eight healthy adult research dogs were separated into one of 5 groups, with each group given different oral doses of aspirin: Dose A, 0.5 mg/kg, q24 h; Dose B, 1 mg/kg, q24 h; Dose C, 2 mg/kg, q24 h; Dose D, 4 mg/kg, q24 h or Dose E, 10 mg/kg, q12 h. Prior to aspirin therapy (Day 0) and again after one week (Day 7) of drug administration, blood and urine were collected to assess platelet function (turbidimetric aggregometry and PFA-100 Ã’ (closur.....
    Document: Eight healthy adult research dogs were separated into one of 5 groups, with each group given different oral doses of aspirin: Dose A, 0.5 mg/kg, q24 h; Dose B, 1 mg/kg, q24 h; Dose C, 2 mg/kg, q24 h; Dose D, 4 mg/kg, q24 h or Dose E, 10 mg/kg, q12 h. Prior to aspirin therapy (Day 0) and again after one week (Day 7) of drug administration, blood and urine were collected to assess platelet function (turbidimetric aggregometry and PFA-100 Ã’ (closure time)) and urine 11-dehydro-thromboxane B 2 (11-dTXB 2 , a stable metabolite of TXA 2 ) and 6-keto-prostaglandin F 1a (6-keto-PGF1 a , a stable metabolite of prostacyclin) synthesis. A dog was considered to be an aspirin responder if there was >25% reduction in maximal amplitude on aggregometry, or the Day 7 PFA-100 Ã’ closure time was >300 seconds.

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