Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_4
Snippet: Our aim is to validate HPLC-MS/MS for the detection of clopidogrel, CAM-D, and other metabolites in feline plasma. We hypothesized that HPLC-MS/MS is both accurate and precise. The quantitation of CAM is the first step in determining if cats can consistently metabolize clopidogrel or if significant interindividual variation exists as in humans with genetic polymorphisms of hepatic cytochrome P450. Furthermore, having an accurate and precise metho.....
Document: Our aim is to validate HPLC-MS/MS for the detection of clopidogrel, CAM-D, and other metabolites in feline plasma. We hypothesized that HPLC-MS/MS is both accurate and precise. The quantitation of CAM is the first step in determining if cats can consistently metabolize clopidogrel or if significant interindividual variation exists as in humans with genetic polymorphisms of hepatic cytochrome P450. Furthermore, having an accurate and precise method for measuring the plasma concentration of CAM will allow safer use of clopidogrel by potentially establishing a therapeutic index and by evaluating whether coadministration of drugs like omeprazole inhibit CAM formation in cats.
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