Selected article for: "amino acid and intermediate host"
Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
  • Document date: 2020_4_18
    • ID: 6ne76rh1_32
    Snippet: Phylogenetic analysis of coronaviruses has demonstrated that SARS-CoV-2 most likely originated in a bat species (1) . However, whether SARS-CoV-2 or the progenitor of this virus was transmitted directly to humans or through an intermediary host is not yet resolved. To determine if amino acid substitution analysis and structural information could be used to identify candidate intermediate host species, we undertook a deep comparative genomic, evol.....
    Document: Phylogenetic analysis of coronaviruses has demonstrated that SARS-CoV-2 most likely originated in a bat species (1) . However, whether SARS-CoV-2 or the progenitor of this virus was transmitted directly to humans or through an intermediary host is not yet resolved. To determine if amino acid substitution analysis and structural information could be used to identify candidate intermediate host species, we undertook a deep comparative genomic, evolutionary and structural analysis of ACE2, the SARS-CoV-2 receptor in humans. To accomplish this we drew on the rapidly growing dataset of annotated vertebrate genomes as well as predicted protein sequences from recently acquired whole genome sequences produced by the Genomes 10K-affiliated Bat1K Consortium, Zoonomia, and Vertebrate 8 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.045302 doi: bioRxiv preprint Genomes Project, and other sources (39, 40) . We conducted a phylogenetic analysis of ACE2 orthologs from 410 vertebrate species and made predictions of their likelihood to bind the SARS-CoV-2 S using a score that was based on amino acid substitutions at 25 consensus human ACE2 binding residues (13, 21) . We supported these predictions with comprehensive homology modeling of the ACE2 binding site.

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