Author: Lipkin, W. Ian
Title: Biocontainment in Gain-of-Function Infectious Disease Research Document date: 2012_10_9
ID: 6ma0r3xp_2
Snippet: Given this history, many of my colleagues may expect that I would support gain-of-function research on the avian influenza virus H5N1 at BSL-3. They would be wrong. In both the fictional and West Nile virus examples, the threat was real rather than hypothetical. It was also not contained. In the instance of H5N1 influenza virus, we do not know whether gain-of-function research will lead to a virus that is capable of sustained human-tohuman transm.....
Document: Given this history, many of my colleagues may expect that I would support gain-of-function research on the avian influenza virus H5N1 at BSL-3. They would be wrong. In both the fictional and West Nile virus examples, the threat was real rather than hypothetical. It was also not contained. In the instance of H5N1 influenza virus, we do not know whether gain-of-function research will lead to a virus that is capable of sustained human-tohuman transmission. Furthermore, to our knowledge, the strains developed and in development do not exist outside specialized laboratories in a few major centers with expertise in influenza virus research.
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