2016 ACVIM Forum Research Abstract Program

All horses tolerated both drugs and the combination well without development of any clinical signs of discomfort or pain and neither of the drugs resulted in alterations in blood pressures. Plasma levels of cardiac Troponin I and creatinine kinase fraction MB did not increase due to intraatrial pacing or any of the treatments given. Ranolazine alone and the combination therapy terminated AF faster than in control procedures (P = 0.0178). The combination therapy resulted in decreased AF duration (P = 0.0469) and AF vulnerability (P = 0.0213) but neither of the treatments altered the aERP significantly. Dofetilide significantly increased the QT c -interval at multiple time points. This was, however, not the case when lower doses of dofetilide were administered in the combination procedures.