2016 ACVIM Forum Research Abstract Program

Sixteen horses were enrolled (January) with at least one clinical sign of early PPID listed above and diagnostically confirmed by the TRH stimulation test measuring ACTH at 0 (T0ACTH; pre-TRH) and 10 (T10ACTH) min following 1 mg i.v. TRH administration. Fasting insulin and glucose was also determined pre-treatment and at each follow-up visit. Each horse was administered PrascendÃ’ (pergolide mesylate) orally at a starting dosage of 2 mcg/kg once daily, dosage adjusted to effect if required, but not to exceed 4 mcg/kg daily, per manufacturers label recommendations. A history, physical examination, and TRH stimulation test evaluating T0ACTH and T10ACTH was conducted for 5 months (February through June) following initial treatment administration. The comparative changes to the baseline ACTH levels over time were evaluated using descriptive statistics. The statistical significance of the change in ACTH levels to be evaluated using a confidence interval of 95%.