Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_813
Snippet: The treatment*sampling hour interaction affected abomasal outflow pH for both a single dose and multiple doses of famotidine (P < 0.001). A single dose of intravenous famotidine resulted in a significant increase of abomasal outflow pH as compared to the control group for 4 hours after administration (P < 0.05). When administered every 8 hours, the abomasal outflow pH of the famotidine treated group was greater than the control group for 4 hours .....
Document: The treatment*sampling hour interaction affected abomasal outflow pH for both a single dose and multiple doses of famotidine (P < 0.001). A single dose of intravenous famotidine resulted in a significant increase of abomasal outflow pH as compared to the control group for 4 hours after administration (P < 0.05). When administered every 8 hours, the abomasal outflow pH of the famotidine treated group was greater than the control group for 4 hours after the first dose (P < 0.05), 2 hours after the second dose, and 1 hour after the third dose (P < 0.05). Pharmacokinetic analysis demonstrated that famotidine had a terminal half-life of 3.33 (3.21 -3.54; median and range) hours, a volume of distribution of 0.042 (0.014 -1.89) L/kg and a clearance of 1.26 (0.625 -11.5) mL/min/kg.
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