2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Although further studies are needed to know the frequencies of the gene mutations, findings obtained in the present study will lead to the introduction of molecular targeted therapy directed to PI3K/Akt, MAPK/ERK, and p53 pathways in canine HS. and age-and breed-matched (in dogs) and age-matched (in cats) to cases. SDMA and creatinine concentrations were compared between cases and controls by cancer type. SDMA concentrations were significantly higher in dogs and cats with lymphoma (P < 0.0001) and significantly lower in dogs with lipoma, mammary adenocarcinoma and mammary carcinoma (P ≤ 0.003) as compared to controls. Creatinine concentrations were significantly lower in dogs with mammary adenocarcinoma and mammary carcinoma and in cats with lymphoma (p≤0.0008) when compared to controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to determine the association between SDMA and tumor type ( Table 1 ). The results indicate that in both cats and dogs, cases of lymphoma are associated with increased SDMA concentrations with a large portion of these cases having concurrent creatinine concentrations within the reference interval.