2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Our study showed that circulating concentrations of some AA were affected in dogs with PDH, indicating that chronic hypercortisolemia may precipitate a disturbance in AA metabolism. Further studies are necessary to clarify the association between AA profiles and consequences of hypercortisolemia in dogs. Canine diabetes mellitus is a common disease that may have parallels to human type 1 diabetes (T1D). We recently identified variances in serum metabolomic profiles between fasted diabetic and healthy dogs, some having similarities to those previously identified in human T1D patients. Given that obtaining fasted samples in diabetic dogs can be difficult in practice, the purpose of this study was to expand these efforts to compare untargeted metabolomic profiles in nonfasted diabetic and healthy control dogs.